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CRT0066854 hydrochloride
CAS No. 2250019-91-9
CRT0066854 hydrochloride ( —— )
产品货号. M32867 CAS No. 2250019-91-9
CRT0066854 hydrochloride 是一种强效选择性非典型 PKCs 抑制剂。CRT0066854 hydrochloride 抑制 PKCι，PKCζ 和 ROCK-II 的 IC50 的值分别为 132nM，639 nM 和 620 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥426 | 有现货 |
|
| 5MG | ￥622 | 有现货 |
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| 10MG | ￥1026 | 有现货 |
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| 25MG | ￥1681 | 有现货 |
|
| 50MG | ￥2495 | 有现货 |
|
| 100MG | ￥3481 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CRT0066854 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CRT0066854 hydrochloride 是一种强效选择性非典型 PKCs 抑制剂。CRT0066854 hydrochloride 抑制 PKCι，PKCζ 和 ROCK-II 的 IC50 的值分别为 132nM，639 nM 和 620 nM。
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产品描述CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
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体外实验CRT0066854 hydrochloride displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates.CRT0066854 hydrochloride (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and themaximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM.
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体内实验——
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同义词——
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通路Cell Cycle/DNA Damage
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靶点ROCK
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受体ROCK | PKC
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研究领域——
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适应症——
化学信息
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CAS Number2250019-91-9
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分子量488.48
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分子式C24H27Cl2N5S
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纯度>98% (HPLC)
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溶解度——
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SMILESN[C@@H](CC1=CC=CC=C1)CNC2=C3C4=C(CCCC4)SC3=NC(C5=CC=NC=C5)=N2.Cl.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kj?r S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J.?2013 Apr 15;451(2):329-42.?
产品手册
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